| 摘要： | 1.1. Aim: Ulcerative colitis, a chronic relapsing form of inflammatory bowel disease, is often neglected at initial stages due to its difficulty in detection leading to delayed clinical evaluation and treatment. Fenugreek, an annual plant and spice, is known to possess anti-inflammatory property. We examined the effect of dietary fenugreek on inflammatory cells related cyto-kinemediated inflammation in dextran sulfate sodium (DSS)-induced colitis model.1.2. Methods: To investigate the anti-inflammatory effect of fenugreek on DSS-induced
ulcerative colitis, DSS (3% w/v) was administered in drinking water for 7 days to induce ulcerative colitis in C57BL/6 mice. Fenugreek (5% and 10%) was fed in diet throughout the experiment for 14 days.
1.3. Results: Fenugreek improved disease activity index, stool consistency, and occult
blood. In addition, it increased colon length and decreased colon weight/length ratio, and
spleen weight. Additionally, it significantly decreased circulating immune cells and mast cell recruit-ment and improved hematological parameters. Further, it altered the acidic and
neutral mucin in the colon and attenuated inflammation by decreasing tumor necrosis
factor-α, interleukin (IL)-1β, and IL-6, but increasing IL-10.1.4. Conclusion: Fenugreek decreased inflammatory cytokines, thereby protecting the colon against DSS-induced inflammation and injury. |
