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    逆式肉桂酸轉換成順式形式可顯著增加多重抗藥性結核桿菌之殺菌力及協同作用.PDF
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    逆式肉桂酸轉換成順式形式可顯著增加多重抗藥性結核桿菌之殺菌力及協同作用.PDF檔名:1426002678762.PDF
    篇名/題名:Transformation of cinnamic acid from trans- to cis-form raises a notable
    摘要:Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis. The long course of treatments on TB with a combination of antibiotics leads unfavorable side effects and poor patient compliance
    which contributes to sustaining multiple-drug resistant tuberculosis (MDR-TB). Therefore, the development of a new effective drug or synergist to reduce the prevalence of MDR-TB is urgent to date. Cinnamic
    acid (CA) is a natural occurring phenolic compound with anti-microbial activity. Both trans- and cis-isoforms of CA exist in planta, and cis-cinnamic acid (c-CA) can be transformed from trans-cinnamic
    acid (t-CA) under sunlight. Due to the unavailability of c-CA, the literature regarding the biological functions
    of c-CA is still limited. We had previously developed a practicable method for the transformation of c-CA from t-CA and the isolation of c-CA. Using the techniques, sufficient c-CA was obtained to evaluate
    its antituberculosis activity against a MDR M. tuberculosis strain. Moreover, the synergistic effects of c-CA and t-CA with two first-line anti-TB antibiotics, isoniazid (INH) and rifampicin (RIF), were also determined. Although both of c-CA and t-CA decreased the viability of MDR-TB bacilli in a dose-dependent manner, the antituberculosis activity of c-CA was approximately 120-fold of t-CA. Furthermore, the c-CA exhibited higher synergistic effect with INH or RIF against tuberculosis than t-CA. The micrographs of scanning electron microscope (SEM) display that c-CA caused an injury on the out-layer of MDR-TB
    bacilli. The c-CA might be a potential anti-mycobacterial or synergistic agent that can be developed to against tuberculosis.
    類型:期刊論文
    西元出版年:2011
    著作語言:en_US
    關鍵詞:cis-cinnamic acidMultiple-drug resistanttrans-cinnamic acidTuberculosis
    作者:翁家瑞、Chia-Jui Weng
    學校系所:生活應用科學碩士班