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    尿激纖~2.PDF檔名:1426002669230.PDF
    篇名/題名:Impact of uPA System Gene Polymorphisms on the Susceptibility
    摘要:ABSTRACT
    Background. The levels of urokinase plasminogen activator(uPA) system in tumor tissues are implicated asprognostic biomarkers in a wide range of malignancies.
    However, their possible impact on the risk and prognosis oforal cancer and the susceptibility of environmental carcinogens
    to oral cancer remains poorly investigated.
    Methods. The genetic polymorphisms of uPA, uPA receptor (uPAR), and plasminogen activator inhibitor
    (PAI)-1 were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) in 253 patients with oral cancer and 344 healthy controls.
    Results. There was no significant effect of uPA system genes on the susceptibility of oral cancer; however, the impact of uPA system gene polymorphisms on the susceptibility of betel nut and tobacco consumptions to oral cancer was revealed, except for that of uPAR gene polymorphism
    on tobacco consumption. Patients with oral
    cancer with at least one 5G allele of PAI-1 gene have a low risk for the development of clinical stage III or IV
    類型:期刊論文
    西元出版年:2011
    著作語言:en_US
    作者:翁家瑞、Chia-Jui Weng
    學校系所:生活應用科學碩士班