Impact of uPA System Gene Polymorphisms on the Susceptibility
摘要：
ABSTRACT Background. The levels of urokinase plasminogen activator(uPA) system in tumor tissues are implicated asprognostic biomarkers in a wide range of malignancies. However, their possible impact on the risk and prognosis oforal cancer and the susceptibility of environmental carcinogens to oral cancer remains poorly investigated. Methods. The genetic polymorphisms of uPA, uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 were analyzed by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) in 253 patients with oral cancer and 344 healthy controls. Results. There was no significant effect of uPA system genes on the susceptibility of oral cancer; however, the impact of uPA system gene polymorphisms on the susceptibility of betel nut and tobacco consumptions to oral cancer was revealed, except for that of uPAR gene polymorphism on tobacco consumption. Patients with oral cancer with at least one 5G allele of PAI-1 gene have a low risk for the development of clinical stage III or IV
